![]() ![]() Faria becomes Dantes’ spiritual “father” and teaches Dantes not only worldly matters of languages, science, and mathematics, but also spiritual matters. He writes the life history of a noble Italian family, the Spada family (who possessed such great wealth that, after the family suffered poisoning, their fabulous treasure remained hidden for centuries until the Abbe Faria was able to decipher the secret message giving the location of this treasure, which Faria, in turn, reveals to Dantes). Thus, virtue is highly rewarded.Ĭlocles A long-time employee in the Morrel firm who remains loyal to the firm, despite its financial difficulties.Ībbe Faria The wise, learned, and lovable political prisoner in the Chateau d’If he is a remarkable and ingenious person, capable of creating some digging tools out of virtually nothing. Maximilien Morrel The son of Monsieur Morrel who will later become not merely a close young friend of the Count of Monte Cristo, but because of his nobility of soul and his devotion and loyalty, he will become the Count of Monte Cristo’s spiritual “son” and the recipient of a great deal of the Count’s fortune. Julie Morrel Herbault Monsieur Morrel’s daughter, who first meets the Count of Monte Cristo as “Sinbad the Sailor” he sends her on an errand to obtain monies which will save her father’s business. Later, upon learning about these facts, the Count of Monte Cristo is able to return the favors triple-fold, for not only does he save Monsieur Morrel’s life, but he is able to recover Monsieur Morrel’s fortune. When he learns of the death of Edmond Dantes’ father, Morrel arranges the proper ceremonies. Likewise, when Dantes is imprisoned, Monsieur Morrel risks his reputation by continually applying for Dantes’ release, even though politically it is an extremely dangerous thing to do. ![]() This act causes the antagonism of others. At the beginning of the novel, when the captain of one of his ships dies en route home, Monsieur Morrel is so impressed with the way that the young, nineteen-year-old Edmond Dantes takes over the captainship of the Pharaon that he makes him captain of the ship. Monsieur Morrel, a shipbuilder and shipowner This is a kindly man interested only in doing good for others and for his family. ![]() Likewise, those people, like Monsieur Morrel, who treated Dantes’ father kindly when he was in despair, come into the good graces of Monte Cristo and are rewarded by him. Monsieur Dantes, Pere Edmond Dantes’ old father, for whom he has a deep devotion - so deep, in fact, that part of the revenge which he takes against his enemies is due to the fact that their treatment of his father caused him to die of starvation. The largest portion of the novel deals with his unique methods of effecting this revenge against his enemies, who became, during Dantes’ fourteen years of imprisonment, very powerful and very wealthy people. Then he devotes his life to bringing about God’s retribution against the evil people who were responsible for his imprisonment. The rest of his life is spent, at first, performing acts of goodness and charity for the good people whom he has known. He becomes the Count of Monte Cristo and dedicates himself to becoming God’s avenging angel. They become as father and son, and when the Abbe is about to die, he reveals to Dantes the hiding place of a long-secret buried treasure, consisting of untold wealth in gold coins, diamonds, and other precious jewels.Īfter fourteen years of bitter imprisonment and hardships, and after a very daring and miraculous escape, Dantes is able to discover the buried treasure on the island of Monte Cristo, and so he buys the island. When the two men finally meet, the other prisoner turns out to be a learned Abbe, who teaches Dantes many languages, sciences, history, and other subjects. While imprisoned, Dantes hears a fellow prisoner digging a tunnel, and so he too begins digging. Edmond Dantes (alias the Count of Monte Cristo his other aliases are Sinbad the Sailor, Abbe Busoni, and Lord Wilmore) Dantes is the dashing and romantic hero of the novel at the age of nineteen, he is falsely imprisoned for a crime which he did not commit and is kept in the horrible dungeon of the Chateau d’If, where he undergoes unbelievable hardships and sufferings that would destroy an ordinary man. ![]()
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![]() ![]() This hybrid car model can accelerate from 0 to 186 mph in just 12.8 seconds, making it one of the fastest cars in the world.Its hybrid propulsion system can produce up to 1,036 horsepower, and the car can reach a maximum speed of 250 mph.This remarkable performance can be attributed to the advanced engineering technology used in the car's design. The McLaren Speedtail boasts an impressive performance capability This design is meant to reduce air resistance and increase the car's speed.The interior design of the car is also remarkable, featuring an exclusive seating arrangement with a central driver's seat and two passenger seats on each side of the driver.The materials used in the interior of the car are luxurious and of high quality, giving the car a sleek and modern look. ![]() So, buckle up and be prepared for an electrifying ride through the world of this futuristic supercar!Introduction to McLaren SpeedtailThe McLaren Speedtail is a hybrid sports car model manufactured by the well-known British automobile manufacturer, McLaren Automotive.This exclusive car model was first introduced to the public in October 2018 and has been the talk of automobile enthusiasts ever since.Deemed as the successor to the McLaren F1, this car model is in a class of its own.One of the key features of the McLaren Speedtail is its distinct exterior design that showcases an aerodynamic teardrop-shaped body. ![]() If you're a car enthusiast, you must be aware of the latest mclaren">McLaren speedtail">Speedtail that is creating quite a buzz in the automobile world.This supercar has been designed to push the boundaries of performance and innovation.The McLaren Speedtail is not an ordinary car it's a sheer masterpiece that boasts stunning aesthetics and impressive engineering.Today, we will be taking a detailed look at the design and performance of the McLaren Speedtail. McLaren Speedtail Looks Amazing In Forza Horizon 4, mclaren speedtail cars HD wallpaper ![]() ![]() ![]() for assistance scheduling an appointment. Call 1-833-4-ASK-ODH (1-83) Monday through Friday from 9 a.m. If you’re having difficulty with the system, we’re here to help. Accessing and Using the Patient Portal: Quick Reference Guide - These step-by-step instructions show you how to set up your account, cancel an appointment, and complete pre-screening information.On Thursday, March 11, Ohioans who are 50 to. How to Check Eligibility and Schedule a COVID-19 Vaccine Appointment (Video) 1:00 If youre an older Ohioan or part of a growing list of professions and health conditions, its your time to act and get the coronavirus vaccine. Requiring vaccines is becoming much more mainstream, with all Columbus hospitals announcing Tuesday that they would mandate vaccines for all employees.How to Schedule a COVID-19 Vaccination: Quick Reference Guide - A step-by-step guide on how to check eligibility and book a COVID-19 vaccine appointment at. ![]() Vaccine Management Solution (VMS) Frequently Asked Questions. ![]() Once you sign up with the Vaccine Management Solution (VMS), you can get alerts about future eligibility and appointment reminders. This website simplifies the scheduling process, allowing Ohioans to check eligibility, find providers nearby, schedule appointments, and get reminders. Ohioans can access on a smartphone, computer, or tablet. is a website that allows Ohioans to easily determine whether they are currently eligible to receive COVID-19 vaccines or booster doses, to find a vaccine provider, and to schedule an appointment. With the increase in demand, they are filling up quickly so it’s. Ohioans can determine vaccine eligibility, find providers, and receive updates and reminders at . Giant Eagle and most Kroger pharmacies require people getting any COVID-19 vaccine to schedule an appointment online. ![]() ![]() ![]() “I figured out on Lap 155 that everything he was doing was on purpose,” Shank said. Castroneves would pounce when he needed to, provoking the tenacity of drivers nearly half his age all around him. He hadn’t led many laps, but he was there, wasting as little fuel as possible to stay within striking distance. With 50 laps to go, that landmark so many drivers reference as the time when the real race begins, Castroneves’ masterpiece was starting to come into view. So a short ways back he lurked Sunday, letting veterans such as Scott Dixon and Alexander Rossi fall victim to an early fueling frustration, while Will Power spun in the pits and Graham Rahal left his pit box prematurely before his left rear wheel spun off with his own chances. ![]() “Don’t touch the car,” he remembers pleading in the garages that night.Ī champion well-trained on how something so small can alter a car and dash an opportunity, he didn’t want to let this one go. ![]() He went to Meyer and Shank, the two men who promised to throw the kitchen sink at his No. Sunday was the first of six races the 46-year-old was set to run in 2021, despite the driver’s most fervent pleadings.īut when Castroneves finished up last week's post-qualifying practice, sitting eighth on the grid, he was downright giddy. The co-owners were methodical in building Castroneves’ program. We believe in you, and with our technical partnership with Andretti Autosport and as a relatively small team, we can both dedicate you as much attention and resources as anyone. “Of course I thought he had something left in him.” “Jim and I looked at (Helio’s) performance numbers from (his last full-time season in 2017), and I didn’t quite get him not running anymore,” Shank said. Over impassioned late-night chats, the two co-owners of one of Ind圜ar’s smallest outfits, which debuted in 2017 and is only in the midst of its second full-time season with Castroneves’ teammate Jack Harvey, saw this promise in the aging, yet feisty driver.Īnd, quite frankly, they couldn’t understand why Penske no longer could. That’s precisely what Shank and Jim Meyer saw. Oller: Shank's boyhood obsession with cars turns into thriving race team Anytime he’s out there, he’s got a chance.” But, as four-time Indy 500 winner Rick Mears said of Castroneves, “He’s kept that fire lit all these years. Not many gave Shank and Castroneves a chance. Maybe Castroneves would have a shot to win, but he’d also boost a team that needed some veteran leadership at one of the most challenging tracks in the world. Shank, a 1985 Gahanna High graduate, hired Castroneves for the Indy 500 to complement the one-car Pataskala-based Meyer Shank Racing team. No one had ever won an Indy 500 after having not done so in 11 consecutive tries.īut Castroneves, still the last driver to win consecutive Indianapolis 500s in 20, insisted he was not done racing yet. Theirs was a working relationship that had been slowly winding down for years and had run its course. But he was eventually phased over to the sports car program before Roger Penske shuttered the team and cut Castroneves loose. So there is more things to come ahead of us, but as of right now, I want to focus on the Ind圜ar program as well and (the Rolex 24).INDIANAPOLIS - Helio Castroneves spent more than two decades driving for Team Penske and won three Indy 500s with the group. We just got to elaborate a little bit more to give me a little more experience on that. So as of right now, yes, it's not going to happen,' Castroneves said. "I believe it would be a little bit tough throwing myself in such a short notice, and to go in a place that you've got to race yourself into it. A potential Daytona 500 bid for Castroneves was sparked in last year's SRX season opener at Five Flags Speedway, which came after the 47-year-old Brazilian had made a bet with SRX CEO Don Hawk that he'd have to find him a ride in the Daytona 500 if he won an SRX race.Ĭastroneves cited a lack of experience racing stock cars and a lack of testing as to why he choosing not to run in the race. Despite months of documented interest on his part, four-time Indianapolis 500 champion Helio Castroneves ruled out attempting to qualify for the 2023 Daytona 500 during a media availability ahead of this weekend's Rolex 24 at Daytona.Īccording to NBC Sports, Castroneves had been negotiating with The Money Team Racing concerning a potential bid to qualify for his NASCAR debut. ![]() ![]() The calculator will generate a step-by-step explanation on how to obtain the results. The fraction calculator will compute the sums, differences, products or quotients of fractions and decimals. You can enter up to 3 digits in length for each the numerators and denominators (e.g., 456/789). This online fraction and decimal calculator will help you understand how to add, subtract, multiply or divide fractions and decimals. Fractions: Enter as 3/4 which is three fourths or 3/100 which is three one hundredths.Whole numbers: Up to 3 digits in length.You can enter up to 3 digits in length for each whole number, numerator or denominator (123 456/789). Keep exactly one space between the whole number and fraction and use a forward slash to input fractions. Mixed numbers: Enter as 1 1/2 which is one and one half or 25 3/32 which is twenty five and three thirty seconds.The answer is provided in a reduced fraction and a mixed number if it exists.Įnter mixed numbers, whole numbers or fractions in the following formats: This online calculator handles simple operations on whole numbers, integers, mixed numbers, fractions and improper fractions by adding, subtracting, dividing or multiplying. Mixed Numbers Calculator (also referred to as Mixed Fractions): The Mixed Numbers Calculator can add, subtract, multiply and divide mixed numbers and fractions. Those are the methods to add or subtract fractions but you can also use fraction calc to solve fraction problems without any hassle of actual computation.Do math calculations with mixed numbers (mixed fractions) performing operations on fractions, whole numbers, integers, mixed numbers, mixed fractions and improper fractions. Both fractions will be represented by tally marks until both denominators will be equal. This method may not be used in some schools but at least it can represent a new way of adding or subtracting fractions. This method is introduced by Ky Davis from Muskingum University. So by counting the boxes below, the answer of ¼ + 2/3 will be 11/12. The total boxes will represent the new denominator. Now the boxes that are filled with Xs or Os represent the sum and will become the new numerator. To represent the 2/3 fraction, fill the first and second rows with Xs.Īfter filling with Xs and 0s, the result will be seen below.įor boxes with both X and O, move the X to an empty boxes. To represent the 1/4 fraction, fill the first column with 0s. This is the same as multiplying the two denominators. You need to make 4 columns and 3 rows to represent the denominators. So Grid method should be taught in elementary or even in kindergarten education.įollow the steps below to perform the Grid method. Learning fraction through visualization is one of the most effective methods suitable for young learners. This method is suitable for people that are good visual learners. The product of the rows and columns will represent the new denominator the sum of the numerators will be the new numerator. This method uses rows and columns to represent the denominators. The Grid method is applicable only for two fractions at a time. The result will be their new denominator. For the denominator, you will multiply the first denominator to the second denominator. You will multiply the first numerator to the second denominator and second numerator to the first denominator. This method is very easy method because you just have to cross-multiply. The result will the new numerator and the denominator will be the LCM. ![]() Use the LCM to make like fractions by dividing the LCM to the denominator and multiply the answer by the numerator. This is the least common multiple or LCM. List all the multiples of each denominator.įind the smallest or the least multiple that is common to all denominators. The steps in applying method are listed below. This is the chosen method used in teaching elementary and high school students. This is the most popular method of adding and subtracting unlike fractions. These methods are listed and explain below. Those fractions that have different denominators, there are four methods to make their denominators the same before applying the general rule. Those fractions which have the same denominators are called like fraction. ![]() This is applicable only if the fractions have the same denominator. This is the general rule in adding and subtracting fractions. ![]() ![]() Add or subtract numerators only while the denominator will remain the same. ![]() ![]() ![]() I used a thin wire and sandwiched it between the fuse and the slot of the socket that read 0 volts. This will provide 12 volts to the PCB once the fuse is in and if something goes terribly wrong, the fuse will burn out. ![]() We will use the slot that does not read voltage (use the one that reads 0 volts). Now find which of the 2 slots of this fuse socket reads voltage. Now place the key in and turn to "ON" position so as to listen to the radio. ![]() We are looking for a fuse that is not hot when the key is "OFF". If it reads voltage, again try another fuse. If it reads 0 volts, place the red probe on the other slot. If it reads voltage (not 0), try another fuse. With a voltmeter, connect the black probe to the car's ground and the red to one of the 2 slots of the fuse's socket. To locate which fuse to use, disconnect any fuse. On my '99 Ford Explorer, I picked fuse #12 on the interior fuse panel which happens to be used for the windshield wiper pump. Finally, 2 heavy gauge wires will provide the coolant probe. A car's ground is any exposed metal connected to the car's chassis so I found a narby bolt provided a good ground. 2 wires will provide voltage for 2 LED's and another provides their ground. This supplies 12 Volts from the car's battery. The ground wire will connect the ground on the PCB to the ground on the car. 1 wire connects a fuse, which is hot when the key is "ON" or engine is running, to the voltage in on the PCB. The PCB will have a few wires connected to it. Technically, this project uses an equivalent circuit to my " Electronic Diaper" project in that it uses a voltage divider connected to an ADC (analog to digital converter) pin. This way, it's most efficient in power consumption while it's turned on. The indicator is microcontroller based and it incorporates built-in hardware features called "sleep mode" and "watchdog timer" to periodically wake up, take a reading, flash the corresponding LED, and go back to sleep. By choosing the right fuse in your car, the indicator is turned on only when the car is running or the key is in the "ON" position. Otherwise, a red LED flashes if it's low or empty on coolant. A green LED flashes when there is coolant in the reservoir. This instructable does not cover troubleshooting the source of the problem however. The idea is that the coolant reservoir will likely go empty before the radiator does and while the coolant level in the reservoir changes as you drive, an empty reservoir is a good indicator of a problem.Ĭoolant loss could be the result of any number of things including a bad water pump, bad gasket, or broken hose. While most cars have a temperature gauge alerting you of overheating, they fail to warn you of the issue in time to resolve it before the likelyhood of a broken engine. Today I will show you how to tell when your car is experiencing coolant loss by building and installing a low coolant indicator in the coolant reservoir. ![]() ![]() ![]() Maybe you want to create a cozy, comfortable bedroom that feels like home. Your bedroom even has an aesthetic bed to create a comfy sleep space, complete with cozy bedding and colorful or patterned pillows. The room features plenty of greenery and neutral tones, with little pops of color through accessories. If you are looking for other aesthetic bedroom ideas for small rooms, look no further than a bedroom in a white base with hardwood flooring and calming decor. Small Aesthetic Bedroom Photo by Pinterest You can add purple accessories and decor such as blankets, throw pillows and rugs, but you can also take it up a notch with purple LED lighting. Purple is a color that represents bravery, wisdom and spirituality, which is perfect for enhancing your bedroom aesthetic and improving your mood. One example is an aesthetic purple bedroom. Your aesthetic may feature a specific color, and that is okay because this is a color you find beautiful. Aesthetic Purple Bedroom Makeover Photo by Pinterest It is also a great way to create an oasis without overdoing it. White Bedroom with Plants Photo by Schoolhouseĭo you have a more simple taste than bold colors and string lights? Why not add greenery to a white bedroom? This design actually works for a small aesthetic bedroom because the white base makes the room feel bigger and brighter, while the greenery improves the air quality and adds color to your space. One way to achieve your neon aesthetic design is to look into the LED Laser Star Projector, which is perfect for gazing at the stars from your own bed. ![]() You can go for an outer space feel rather than a neon-light look. If you are a fan of neon lights, colors and designs, use these elements to create an aesthetic that is truly out of this world. ![]() You can be as creative as you want when coming up with a Boho aesthetic that makes you feel happy. From bold colors to Bohemian chairs to gorgeous greenery, it is easy to find aesthetic room decor that fits the Boho design. Boho Aesthetic Bedroom Photo by A TASTE OF KOKOĪ small Boho bedroom is perfect if you are looking for a design that gives you the freedom to play with colors, patterns and textures. By choosing decorative LED lights, you are creating a cute design that helps you save energy. Imagine LED string lights on the wall behind your bed and nightstand. The lighting you choose can transform your space, especially when you look into aesthetic bedroom ideas with LED lights. Aesthetic Bedroom Decor with LED Lights Photo by roombodi Are you ready to change up the vibe of your bedroom? Use the following aesthetic bedroom ideas to draw inspiration for your space. In addition, we are including the aesthetic bedroom pictures to help you get a better idea of these beautiful designs. Instead, we have chosen 23 aesthetic room ideas that fit various tastes and spaces, and this should make it easier to find an idea that catches work for you. There are so many aesthetic room ideas to consider for your space, we could not choose just one aesthetic design for this guide. 23 Aesthetic Bedroom Ideas For Your Space You can make your bedroom more aesthetic by thinking about the elements you find beautiful, as well as the elements that boost your overall mood. So, what do you find beautiful? Is it a certain color scheme? Lighting? Greenery? Maybe it is certain pieces of decor. The definition of aesthetic is “concerned with beauty or the appreciation of beauty.” You do not have to follow any strict rules to create an aesthetic room. Also known as esthetic, an aesthetic room allows you to use your creativity and interests to enhance the beauty of your space. You can choose from a range of bedroom designs, but you may want to look into an aesthetic bedroom. Sometimes, you just need a change of scenery, even in your own space. It is not uncommon to want to change the vibe of your bedroom. ![]() ![]() ![]() Robust SQL firewalling and proxy capabilities.Automatic failover, transaction replay, and session restore.Federated servers and database interconnect via ODBC.Distributed SQL with high availability, fault tolerance and write-scaling.Distributed analytical processing with columnar storage, backed by low-cost object storage.MariaDB Platform X5 further extends these capabilities with: Columnar storage for analytics, since 2020.Temporal Tables (System-Versioned, Application-Time Period, Bitemporal), since 2019.Advanced InnoDB online DDL with instant ALTER, since 2019.Compatibility with a subset of Oracle PL/SQL, via SQL_MODE=ORACLE, since 2018. ![]() Core features and behavior familiar to at least a third of developers worldwide (per Stack Overflow Developer Survey 2020).Availability from leading cloud providers worldwide.Data-at-Rest and Data-in-Transit Encryption.Common Table Expressions and Window Functions.InnoDB storage engine for ACID-compliant transactions. ![]() MariaDB Community Server and MySQL Server Community Edition, both Open Source, have over the years been packaged for many of the same Linux distributions, powering application stacks behind hundreds of popular websites and applications. Looking back in MariaDB Server’s family tree, we find its ancestor, MySQL Server. What we conclude: MariaDB provides superior performance on commodity cloud hardware for real business workloads. Where we tested: Amazon AWS EC2 and RDS, large to 12xlarge instances How we tested: Multi-statement, transaction processing workload (Sysbench 90:10) Aurora RDS offers superior high availability to RDS due to the unique storage subsystem.What we tested: Relative performance of MariaDB vs MySQL.The pricing models differ slightly between RDS and Aurora RDS, but Aurora RDS is generally a bit more expensive to implement for the same database workload.Aurora RDS offers superior scalability to RDS due to the unique storage subsystem.Aurora RDS offers superior performance to RDS due to the unique storage subsystem.RDS offers a greater range of database engines and versions than Aurora RDS. ![]() When comparing the two platforms to select the best architecture for a particular application stack, the following should be taken into consideration. The regular RDS and Aurora RDS offerings for MySQL and PostgreSQL are more similar than they are different. Many of our customers struggle to understand the differences between regular RDS and Aurora RDS, so to alleviate that confusion this article was written to shed some light on the key differences between RDS MySQL and RDS Aurora MySQL. Unlike standard RDS, it supports only a subset of the database engines.” Currently, only MySQL and PostgreSQL are supported in RDS Aurora.
![]() ![]() Something highly useful so that I can work on my Priorities. I can look at my life at different angles. Last but not least I like that OmniFocus allows me to "focus" and "zone in" on something. I also use external Attachments, and a script to copy a Mail.app's mail URL to the clipboard. I use a TextExpander snippet called "update", it inserts some "-" along with the current date and time. When I go back to a task, that I had deferred previously, it is good to know what caused the deferral. Making meeting notes is super important to me. But having the ability to give a task any length of text (with formatting) is highly useful. OmniFocus also has comments, which may be an underestimated feature for some. Also there's Chris' Templates.scpt script which makes awesome things. Python is a really good and popular (scripting) language at the moment, but, I don't know, I'm just more of an AppleScripter. ![]() I know AppleScript is not everybody's favorite. Let's not forget that OmniFocus has AppleScript support. A review of that app will be appearing soon.There's more. If you are looking for alternatives to xPlan, consider OmniGroup’s OmniPlan for the iPad. Confidently work on your project with other OmniPlan users by syncing either through Omni’s servers using a free Omni Account or by using your own WebDAV server. – Send an email with a PDF version or XML version of the project – Print to printers compatible with AirPrint wireless technology – Support of external screens or video projector to showcase your projects on a big screen – Reports view (global view of all settings and related costs of a project) Check Capterra to compare OmniPlan and Project Reader based on pricing, features, product details, and verified reviews. – Innovative resources view (allows you to see all tasks related to a resource in a calendar view) – Linked tasks and processes (when you move a linked task, all next tasks will follow) ![]() – Gantt view (create beautiful and professional charts in minutes) – To do Management (add special tasks related to a projet) – Events management (add meetings, special events related to a project) ![]() – Tasks and Sub Tasks management with completion level and cost (sub tasks are called processes) – Full resource management (human and material). Just compare our software to that of any of our competitors and you will experience the difference! xPlan delivers beautiful, concise graphics that are sure to impress customers and colleagues and help you efficiently complete all your projects. You will be successfully managing even the most complex projects in a fraction of the time it would take you with other similar products. The Gantt Chart gives you a graphical representation of your projects including tasks, resources, start and end dates, milestones and completion. xPlan makes it easy to specify requirements, tasks, resources, and obstacles, and to generate a full Gantt schedule, including task dependencies. OmniPlan for Mac price starts at 199 per license, When comparing OmniPlan for. Microsoft Project price starts at 10 per user/month, On a scale between 1 to 10 Microsoft Project is rated 4, which is lower than the average cost of Project Management software. If you prefer to purchase OmniPlan as a one-time traditional license, OmniPlan Standard is available for. We prepared a TCO (Total Cost) calculator for Microsoft Project and OmniPlan for Mac. Maybe they just want a simple tool they can use to provide initial requirements and to view your full-featured plans. OmniPlan Pro subscriptions are available for 19.99 a month or 199.99 for an entire year. If you are a professional project manager, you might be tired of trying to train your team to use an expensive and complicated tool. Of course, it’s got to pump out a professional project management plan too. If you’re not a professional project manager, you probably want something that’s easy to learn and inexpensive. Send your bug reports to xPlan, creating, tracking and managing your projects will be much easier than ever! xPlan is designed to keep track of tasks and calculate a project’s cost. The developer describes the app as follows:īETA VERSION : help us to find issues and bugs of this new version. The app regularly sells for $29.99 and is being offered for free to help the developer find issues and bugs in this version. XPlan 3.0.1 is a beta version of a project management tool for the iPad. ![]() ![]() Pathologic complete response and risk of breast cancer recurrence 11 This paper will discuss the basis for using pCR as a surrogate endpoint in breast cancer, compare the validity of pCR amongst different immunohistochemistry-based receptor subtypes (or simply, receptor subtypes) of breast cancer, examine the relationship between pCR and survival, and evaluate whether or not pCR meets the criteria of a valid and useful surrogate endpoint. 6 This decision was somewhat controversial because the relationship between pCR and hard survival endpoints is not straightforward, 10 and the definition of pCR can vary between studies. 9 However, FDA approval for the use of pertuzumab in the neoadjuvant setting was based on a primary endpoint of pCR in the NeoSphere study. 1,6–8 Pertuzumab, for example, a monoclonal antibody used to treat human epidermal growth factor receptor 2 (HER2) positive (HER2+) breast cancer, was originally approved by the US Food and Drug Administration (FDA) in the metastatic setting based on the primary endpoint of overall survival (OS) in the CLEOPATRA study. In breast cancer, neoadjuvant trials have become an increasingly common setting in which to develop and gain approval for new drugs. Neoadjuvant trials, in contrast, which study therapies administered prior to surgical intervention and commonly utilize the post-operative surrogate endpoint of pathologic complete response (pCR), offer a more efficient and potentially beneficial framework for drug development. Adjuvant trials, which study therapies administered following surgical intervention, may offer patients an increased chance of cure, but they also generally depend on survival endpoints for analysis, which, in the case of estrogen receptor positive (ER+) breast cancer, can take years (or even decades) to complete. 1–4 Furthermore, these trials are often lengthy and expensive because they typically depend on survival endpoints in order to gain regulatory approval or to be considered for use in earlier disease stages. These trials, however, often involve sicker patients who can confound the results, and do not directly offer patients the chance of cure. This seems like a natural population in which to start because patients have often exhausted the armamentarium of approved agents and, therefore, clinical equipoise is easier to achieve. The metastatic setting has traditionally been the initial venue for the development of new drugs in breast cancer. Keywordsīreast cancer, chemotherapy, neoadjuvant, pathologic complete response Article: ![]() This review discusses the basis for using pCR as a surrogate endpoint in breast cancer, compares the validity of pCR amongst different receptor subtypes of breast cancer, examines the relationship between pCR and event-free survival, and evaluates whether or not pCR meets the criteria of a valid and useful surrogate endpoint. Neoadjuvant trials, however, which commonly utilize the post-operative surrogate endpoint of pathologic complete response (pCR), offer a more efficient and potentially beneficial framework for drug development. ![]() |